CCBS - Centre for Clinical Brain Sciences

Name:Dr Cathie Sudlow 
Telephone:+44 (0)131 537 2872 
Fax:+44 (0)131 332 5150 
Work Address:Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK 
Job Title:Professor of Neurology and Clinical Epidemiology Chief Scientist for UK Biobank  
Speciality:Research: Epidemiology and genetics of stroke; large scale observational epidemiology; epidemiology of neurodegenerative diseases

Clinical: General neurology and stroke  
Qualifications:BA (Cantab), BMBCh (Oxon), MRCP, MSc Epidemiology (Lond), DPhil (Oxon), FRCPE  

Research Overview: 

My group’s main interests are in classical and genetic epidemiological approaches to understanding different subtypes of stroke, and – through my involvement with UK Biobank and collaboration with other very large cohorts (including Million Women Study and China Kadoorie Biobank) - large scale prospective observational epidemiology. Our work will evolve over the years ahead to encompass prospective studies of neurodegenerative disorders as well as of stroke and related phenotypes

Research Direction:

Classical and genetic epidemiological approaches to understanding different stroke subtypes
I have a longstanding interest in the global epidemiology of stroke and have made important contributions in this area. I lead a programme of work investigating epidemiological differences between stroke subtypes, including: analyses of data from a hospital-based study of >2000 stroke/transient ischaemic attack (TIA) patients (the Edinburgh Stroke Study); collaborative individual patient data pooling efforts; and systematic reviews. Complementing this is a programme of work on genetics of stroke and related phenotypes, including meta-analyses and collaborative genome wide association studies.

UK Biobank
UK Biobank is a prospective study of 500,000 participants, recruited and extensively phenotyped from 2006-2010 at the age of 40-69, and now being followed up for the occurrence of a range of health-related outcomes ( As UK Biobank’s Chief Scientist, I lead the follow-up programme, coordinating linkages to national death, cancer, hospital, primary care and other datasets, and nine expert outcomes adjudication subgroups (cancer, diabetes, cardiac, stroke, neurodegenerative, mental health, musculoskeletal, respiratory, ocular outcomes). I lead the work on stroke outcomes and co-lead the work on neurodegenerative outcomes. I play a key role in UK Biobank’s other programmes of work, including liaison with scientists about development and use of the resource, streamlining open access procedures, and developing procedures for feedback of incidental findings as part of a large multi-modal imaging sub-study.

Other stroke and related research
I am a co-investigator in several randomised trials of preventive interventions in patients with stroke/TIA; studies of brain imaging characteristics of cerebrovascular disease; studies of outcome prediction after stroke; and studies (observational & interventional) of adherence to secondary preventive medications after stroke/TIA.'

Board Membership: 

  • Advisory Board, UK Clinical Practice Research Datalink
  • UK Biobank: Executive Management Team, Steering Committee, Longitudinal Follow-up Group, Imaging Working Group
  • Chair, Association of British Neurologists Stroke Section
  • Chair, British Association of Stroke Physicians Scientific Committee
  • Prevention Clinical Studies Group, UK NIHR Stroke Research Network
  • Data and Safety Monitoring Board, TARDIS (international, multicentre, randomised trial of antiplatelet therapy after TIA or ischaemic stroke)
  • Trial Steering Committee, RESTART (international, multicentre, randomised trial of antiplatelet treatment after intracerebral haemorrhage)
  • Trial Steering Committee, TELESCOT (programme of randomised trials of telemetric supported home monitoring of chronic conditions)

Recent Publications: 

  • Tsai J, Thomas BM, Sudlow CLM. Epidemiology of stroke and its subtypes in Chinese compared with whites – systematic review. Neurology 2013; 81: 264-272.
  • Traylor M, Bevan S, Rothwell PM, Sudlow C, et al. Using phenotypic heterogeneity to increase the power of genome-wide association studies: application to age at onset of ischaemic stroke subphenotypes. Genet Epidemiol 2013; 37: 495-503.
  • Rannikmäe K, Samarasekera N, Martînez-Gonzâlez NA, Al-Shahi Salman R, Sudlow CLM. Genetics of cerebral amyloid angiopathy: systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2013, doi:10.1136/jnnp-2012-303898.
  • Williams FM, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, Traylor M, Bevan S, Dichgans M, Rothwell PM, Sudlow C, et al. Ischemic stroke is associated with the ABO locus: the EuroCLOT study. Ann Neurol 2013;73: 16-31.
  • Traylor M, Farrall M, Holliday EG, Sudlow C, et al. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association Lancet Neurol 2012;11:951-962.
  • Bevan S, Traylor M, Adib-Samii P, Malik R, Paul NLM, Jackson C, Farrall M, Wellcome Trust Case Control Consortium 2, Rothwell PM, Sudlow C, et al. Genetic heritability of ischaemic stroke and the contribution of previously reported candidate gene and genome wide associations. Stroke 2012; 43:3161-3167.
  • Allen N, Sudlow C, Downey P, Peakman T, Danesh J, Elliott P, Gallacher J, Green J, Matthews P, Pell J, Sprosen T, Collins R on behalf of UK Biobank. UK Biobank: current status and what it means for epidemiology. Health Policy and Technology 2012;1:123-126.
  • Holliday EG, [52 authors], Sudlow C, et al. Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Nat Genet 2012; 44:1147-1151
  • Krafft PR, Bailey EL, Lekic T, Rolland WB, Altay O, Tang J, Wardlaw JM, Zhang JH, Sudlow CLM. Etiology of stroke and choice of models. Int J Stroke 2012;7:398-406.
  • International Stroke Genetics Consortium (ISGC) and Wellcome Trust Case Control Consortium 2 (WTCCC2). Genetic analysis identifies a new susceptibility locus in HDAC9 for large vessel ischemic stroke, and supports genetic heterogeneity across stroke subtypes. Nat Genet 2012;44:328-323.
  • Whiteley W, Jackson C, Lewis S, Lowe G, Rumley A, Sandercock P, Wardlaw J, Dennis M, Sudlow C. The association of circulating inflammatory markers with recurrent vascular events after stroke: a prospective cohort study. Stroke 2011;42:10-16.
  • Maxwell SS, Jackson CA, Paternoster L, Cordonnier C, Thijs V, Salman R A-S, Sudlow CLM. Genetic associations with brain microbleeds: systematic review and meta-analyses. Neurology 2011;77:158-167.
  • Paternoster L, Martinez-Gonzalez N, Charleton R, Chung M, Lewis S, Sudlow C. Genetic effects on carotid intima-media thickness (CIMT): systematic assessment and meta-analyses of candidate gene polymorphisms studied in over 5000 subjects. Circ Cardiovasc Genet 2010;3:5-21.
  • Jackson CA, Hutchison A, Dennis MS, Wardlaw JM, Lindgren A, Norrving B, Anderson CA, Hankey GJ, Jamrozik K, Appelros P, Sudlow CL. Differing risk factor profiles of ischemic stroke subtypes: evidence for a distinct lacunar arteriopathy? Stroke 2010;41:624-629.
  • The International Stroke Genetics Consortium and Wellcome Trust Case Control Consortium 2. Failure to validate association between variants on 12p13 and ischemic stroke. NEJM 2010;362:1547-1550.
  • Paternoster L, Chen W, Sudlow C. Genetic determinants of white matter hyperintensities on brain scans: a systematic assessment of 19 candidate genes in 46 studies in 19,000 subjects. Stroke 2009;40:2020-2026.
  • Jackson CA, Hutchison A, Dennis MS, Wardlaw JM, Lewis SC, Sudlow CL. Differences between ischemic stroke subtypes in vascular outcomes support a distinct lacunar ischemic stroke arteriopathy: a prospective, hospital-based study. Stroke 2009;40:3679-3684.
  • Whiteley W, Jackson C, Lewis S, Lowe G, Rumley A, Sandercock P, Wardlaw J, Dennis M, Sudlow C. Inflammatory markers and poor outcome after stroke: a prospective cohort study and systematic review of interleukin 6. PLoS Med 2009;6(9):e1000145. doi:10.1371/journal.pmed.1000145.

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